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Professor Peter Holmans
Professor of Biostatistics and Genetic Epidemiology,
Biostatistics and Bioinformatics Unit, UWCM
Academic Qualifications:
BA (Mathematics) Cambridge University
MSc (Statistics) Sheffield University
PhD (Genetic Epidemiology) Cambridge University
Main Research Interests:
I am currently involved in numerous large-scale analyses of complex
genetic disorders, such as late-onset Alzheimer's disease, schizophrenia,
bipolar disorder and recurrent early-onset unipolar depression.
Typically, these involve collaboration with other research groups across
Europe, USA and Australia. My research is therefore primarily focussed on
methods to improve the efficiency of linkage and association studies of
such disorders. Specific topics include:
Inclusion of covariates in model-free linkage analyses, to increase
power by refining the phenotype. In particular, detecting epistatic
interactions between disease loci and using these to increase evidence for
linkage.
Inclusion of covariates into association analyses, particularly when
covariates are only defined for cases (e.g. disease severity).
Testing for imprinting using affected sibling pairs.
Methods for performing tests of association or linkage allowing for the
presence of undetected genotyping errors.
The design of efficient strategies for performing genome scans for
complex traits.
Selected Publications:
 Holmans P (1993) Asymptotic properties of affected sib-pair linkage
analysis. Am J Hum Genet 52:362-374
Holmans P, Clayton D (1995) Efficiency of typing unaffected relatives
in an affected sib-pair linkage study with single-locus and multiple
tightly-linked markers. Am J Hum Genet 57:1221-1232
Holmans P, Craddock N (1997) Efficient strategies for genome scanning
using maximum-likelihood affected sib-pair analysis. Am J Hum Genet 60:657-666
Daniels J, Holmans P, Williams N, Turic D, McGuffin P, Plomin R, Owen
MJ (1998) A simple method for analysing microsatellite allele image patterns
generated from DNA pools and its application to allelic association
studies. Am J Hum Genet 62:1189-1197
Levinson DF, Holmans P, Straub RE, Owen MJ et al. (2000) Multicenter
linkage study of schizophrenia candidate regions on chromosomes 5q, 6q,
10p and 13q: schizophrenia collaborative group III. Am J Hum Genet 67:652-663.
Holmans P (2001) Likelihood-ratio affected sib-pair tests applied to
multiply-affected sibships: issues of power and Type I error rate. Genet
Epidemiol 20:44-56.
Cardno AG, Holmans P, Rees MI, Jones LA, McCarthy GM et al. (2001) A
genomewide linkage study of age at onset in schizophrenia. Am J Med Genet 105:439-445.
Myers A, Wavrant De-Vrieze F, Holmans P et al. (2002) Full genome
screen for Alzheimer disease: stage II analysis. Am J Med Genet 114:235-244
Levinson DF, Holmans P, Laurent C et al. (2002) No major schizophrenia
locus detected on chromosome 1q in a large multicenter sample. Science 296:739-41
Holmans P (2002) Detecting gene-gene interactions using affected sib-pair analysis with
covariates. Hum Hered 53:92-102
Rice KM, Holmans P (2003) Allowing for genotyping error in analysis of
unmatched case-control studies. Ann Hum Genet 67:165-174
Bernardinelli L, Berzuini C, Seaman S, Holmans P (2003) Bayesian trio
models for association in the presence of genotyping errors. Genet
Epidemiol (in press).
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